Manchester United will kick off a new chapter in their pursuit of former glory as Ruben Amorim takes charge for the first time, leading his side in an away fixture at Ipswich Town on Sunday.

As the Premier League resumes after the international break, United’s trip to Portman Road stands out as one of the most intriguing storylines of the weekend. With fans filled with renewed hope after years of decline, the Red Devils are looking for a fresh start under their new head coach, Amorim, who arrives with a reputation for tactical brilliance following a successful tenure at Sporting Lisbon.

Meanwhile, Manchester City, reeling from a four-match losing streak, are determined to bounce back. Despite a five-point gap to leaders Liverpool, City will hope to return to winning ways at home to Tottenham Hotspur on Saturday. The club’s morale was boosted by the announcement that manager Pep Guardiola has signed a contract extension, though questions remain about the team’s recent form.

Liverpool, riding high with a stellar start under new manager Arne Slot, will travel to Southampton, sitting comfortably at the top of the table with 15 wins from their first 17 matches. Arsenal, however, find themselves in need of a revival after collecting just two points from their last four games, leaving them in fourth place, nine points behind Liverpool.

For Amorim, the task ahead is clear: he must quickly restore United to their former prominence. Despite an underwhelming start to the season, with just four wins from 11 matches, United are still within striking distance of the top four, sitting just four points adrift. Amorim, who led Sporting to a famous Champions League victory over Manchester City in his final game in Lisbon, is fully aware of the pressure that comes with managing one of the world’s biggest clubs.

"You feel the history and I'm really proud to be Manchester United's coach," Amorim told MUTV. "I think I am where I'm supposed to be. That’s the feeling."

United will face an Ipswich side high on confidence after their first win since promotion, a 2-1 victory at Tottenham before the international break. Ipswich's victory at Spurs has made them a team to watch as they continue their return to the top flight.

Elsewhere, City’s struggles have coincided with a series of key injuries, but they could be bolstered by the return of Kevin De Bruyne, who has played in only four league games this season, with City winning all of those matches. Without him, they have collected just 11 points from seven games.

Tottenham’s erratic form has seen them record impressive wins over teams like Manchester United and Aston Villa, but also suffer defeats to the likes of Crystal Palace and Ipswich. They will be without midfielder Rodrigo Bentancur, who is serving a seven-match ban for using a racial slur against teammate Son Heung-min.

Chelsea, in third place, will open the weekend’s action on Saturday as manager Enzo Maresca returns to Leicester City, the club he led back to the Premier League last season. "I'm excited and thankful (to return), it was a fantastic season," Maresca said ahead of the match.